Békro Yves-Alain

This research work was carried out on the species Nephrolepis biserrata (Sw.) Schott (Nephrolepidaceae), a fern from Côte d’Ivoire with the aim of establishing its phytochemical, antioxidant and biological profile. The results obtained from the phytochemical screening show that said species contains alkaloids, coumarins, flavonoids, polyphenols, sterols, terpenes, and tannins. The antioxidant activity was evaluated spectrophotometrically against the DPPH radical in comparison with that of vitamin C. The determination of the antibacterial parameters indicates that N. biserrata doesn’t exhibit any bactericidal action against the bacterial strains tested. Regarding the vermicidal activity against earthworms, decocts of N. biserrata showed an anthelmintic effect, which however remains less pronounced than that of albendazole, the anthelmintic antiparasitic taken as a reference.

Gossypium barbadense L. is a medicinal Malvaceae used as an indispensable intrant in the endogenous medication of skin super infection caused by shingles in Côte d'Ivoire. The objective of this study was to study the analgesic and toxic effects in vivo of the extract with ethyl acetate GB2.3, obtained from the hydroalcoholic crude extract of the leaves of Gossypium barbadense L., and to characterize a phytocomponent of the extract. The results obtained showed that the extract showed a significant analgesic effect by inhibition at 73.66% of the pain induced by acetic acid in mice and that it had insignificant toxicity at the dose of 100 mg/kg body weight. A phytocompound was isolated with a yield of 15.21% by HPLC, whose molecular structure was determined by spectrometry (MS, IR, NMR 1H, 13C).