Avish D. Maru

Parenteral delivery provides rapid onset even for the drug with narrow therapeutic window, but to maintain the systemic drug level repeated installation are required which cause the discomfort. Therefore, a delivery system that combines the simplicity and reliability of solid implant devices along with convenience and ease of administration on of micro-particles are desired. In situ gel forming system represents a desired alternate. The atrigel system is a proprietary delivery system that can be used for both parenteral and site specific drug delivery. it consist of biodegradable polymers dissolved in a biocompatible carriers when the liquid polymer system is placed in the body using standard needles and syringes, it solidifies upon contact with aqueous body fluids to form a solid implant. There are some advantages of these system are compatibility with a broad range of pharmaceutical compound, less invasive technique, direct delivery to a target area, protection of drug, sustained drug release, few type of atrigel are surgical implants, microspheres, liposomes and injectable gels.

Oral drug delivery systems most preferred option of administration for various drugs. Sustained release drug delivery system is the novel drug delivery system. The terms Sustained release, prolonged release, modified release, extended release or depot formulation are used to identified drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. Sustained release dosage forms are designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. The basic rationale of sustained release drug delivery system optimizes the biopharmaceutical, pharmacokinetics, and pharmacodynamic properties of a drug in such a way that it’s utility is maximized, side effects are reduced and cure of the disease condition is achieved. Sustained release drug delivery is improved patient compliance due to less frequent drug administration, reduction of fluctuation in steady-state drug levels, maximum utilization of the of the drug, improved therapy and shorter treatment period.