Anil Kumar

Black rot has been a main disease constraint of cabbage grown by farmers in Ranchi. Cabbage is popular cultivars of the species (Brassica oleracia) belong to Cruciferae family. The family cruciferae also includes tomato, cauliflower, beans, broccoli, radish, turnip and pepper. In plain area it is grown mainly as a winter crop, whereas in the hilly areas it is grown as a spring and early summer crop. Cabbage is one of the common and most popular winter vegetables grown in India. In Jharkhand the cabbage is grown almost whole year except in the months when temperature rises up to 40-45 degree Celsius. The purpose of this work was to survey, culturing of isolate from cabbage and confirming the severity of Black rot disease in cabbage in the tribal populated area of Kanke block under Ranchi district of Jharkhand state. In morphology and growth characteristics the all the three isolate resemble those describe by Patel et.al.(1949) and Pandey (1980).It is evident from this the isolates of New Zealand and three local isolates of cabbage were morphologically alike being short rod with rounded ends. They are Gram negative and show positive KOH solubility. On the basis of the possession of many phenotypic properties the three cabbage isolates have been tentatively assigned to this pathogen Xanthomonas campestris pv. Campestris (Xcc) .

The aim of the present work was to develop and optimize gastroretentive floating system of Gemifloxacin mesylate using HPMC polymers, Gelucire 50/13 and Polyox WSR 301 to improve oral bioavailability of Gemifloxacin mesylate floating tablets by increasing gastric residence time. The tablets were prepared by direct compression method. The effect of polymers concentration and viscosity grades of HPMC on drug release profile was evaluated. The result of in vitro dissolution study showed that the drug release profile could be sustained by increasing the concentration of HPMC and Polyox WSR 301. The optimized formulation (F12) containing HPMC K100M, Gelucire 50/13 and Polyox WSR301 showed 99.12% drug release at the end of 12h. The optimized formulations (F12) containing showed desired buoyancy (floating lag time of about 35 seconds and total floating time of >12h). Optimized formulation (F12) followed diffusion controlled zero order kinetics and non-fickian transport of the drug. FTIR studies revealed the absence of any chemical interaction between drug and polymers used.

The main objective of current research work was to develop a stable pharmaceutically equivalent combined dosage form of immediate release Atorvastatin calcium and extended release Metoprolol succinate formulation, which is comparable to that of innovator’s. Combination therapy affords the physician and the patient the opportunity to more effectively treat diseases that may stem from more than one cause. When used correctly and appropriately, combination therapy leads to better outcomes than mono therapy by treating more than one cause of the disease and/or by synergistically enhancing the action of one of the component drugs. The purpose of the study was to develop a capsule of Atorvastatin calcium (IR) and Metoprolol succinate (ER) having different release pattern, which is indicated for the management of hypertension. The study was planned in three stages. In the first stage three batches (A1, A2, and A3) of immediate release blend of Atorvastatin calcium was prepared using pre-gelatinized starch as super disintegrate. In the second stage, nine batches (M1-M9) of Metoprolol succinate sustained release pellets were prepared using various polymers and levels of coatings as rate retardants. Preformulation studies were performed after granulation. In the third stage capsules were evaluated for weight variation, drug content, and disintegration time and in vitro drug release using RP-HPLC. FTIR studies revealed no disturbances in the principle peaks of pure drugs and it confirms the integrity and compatibility of pure drugs with their excipients.