Abubaker Siddiq

Antibiotic Prophylaxis should be appropriate to reduce the risk of postoperative surgical infections. Surgical Site Infections (SSIs) are responsible for Increased Mortality and Morbidity rate during surgical operations which lead to major complications. The inappropriate and overuse of antibiotics effects the cost and efficacy of drugs which leads to the resistant bacteria. To assess the pattern of antibiotic usage in surgical in-patients and for Postoperative wound infections. The present study is a prospective observational study done for a period of six months in Basaweshwara Medical College and Research Centre, Chitradurga in surgical ward. A Total of 162 patients were enrolled into the study. Among them, Surgical Site Infection (SSIs) was found in 37 (22.8%) patients and patients without SSIs are 125 (77.2%). The patients with age group 25-60 years were 104 (64.2%) in which SSIs are more (23).According to the study male patients underwent more surgeries (107 (66%)) in which 21 (56.8%) are with SSIs. Infection rate were more in males when compare to females in the study. A total of 265 antibiotics were used among 162 patients in which third generation cephalosporins are more preferred. The study concludes that there is a proper need to control the use of antibiotics appropriately. The inappropriate use leads to economic burden and resistance. SSIs may decrease the quality of life of the patients. Hence minimization of SSI is also very important in the developing countries by maintaining infection control plans by suitable organizations which makes an impact on the infections

In the current investigation, we have assessed the nephroprotective activity of the 70% ethanolic extract of Tecoma stans leaves (EETSL) against cisplatin, gentamicin and paracetamol (nephrotoxicants) induced nephrotoxicity in rats. Nephrotoxicity is confirmed by elevated kidney weight, blood urea, serum creatinine, lipid peroxidation (LPO), decreased tissue glutathione (GSH) and body weight levels at the administered doses. The ethanolic extract produced reduction in kidney weight, blood urea, serum creatinine, LPO levels and reversed the depleted GSH levels and body weight. This is further confirmed by histopathological studies. The results of the present study reveals that the ethanolic extract of Tecoma stans leaves significantly inhibited the cisplatin, gentamicin and paracetamol induced renal damage in rats and this may be attributed to its antioxidant properties. Key words: Tecoma stans, Lipid peroxidation, GSH, Cisplatin, Gentamicin, Paracetamol, Renal injury.