Simple and Inexpensive Nucleophilic Acyl Substitution of Phenols using Thiol Acetic Acid and Base Catalyst.

The thiol acetic acid and acetic anhydride both has been used for nucleophilic acyl substitution of phenols in two different methods. Both methods are simple and inexpensive by using aqueous NaOH base with acetic anhydride and no catalyst required for thiol acetic acid reaction. This can be a key method for identification of phenolic functional groups.