Design and In-Vitro Evaluation of Sustained Release Matrix Tablets of Glimepiride

The present investigation is to Design and In-vitro evaluation of the sustained release matrix tablets of Glimepiride used for the treatment of type 2 diabetes mellitus. The Glimepiride (6mg) sustained-release (SR) matrix tablets were prepared by wet granulation method using different concentrations of hydrophilic and hydrophobic polymers. Such as Xanthumgum, Microcrystalline Cellulose, Povidone, Guargum, Magnesium Stearate, Pectin. The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. The mixture of Glimipride powder was subjected to pre compression evaluation such as angle of repose, loose bulk density, tapped bulk density, hausarner’s ratio and compressibility index. The FTIR Spectrum is carried for the pure drug and for the optimized formula. This indicated that there was not any interaction between drug and polymer. All the formulations (F1-F12) were evaluated for weight variation, hardness, thickness, Friability, Content uniformity and invitro dissolution. The invitro dissolution studies were performed in pH 7.4 indicated that formulation F8 (Glimepiride and Guar gum in the ratio of 1:6) is the most success full formulation of this study and exhibited drug release 99.2% in 12 hr.  To investigate the drug-release kinetics, data were fitted to various kinetic models such as zero-order, first-order, Higuchi equation, Korsmeyer-Pappas equation, and Hixson–Crowell equation.