Synthesis and Pharmacological Evaluation of Novel 1-(2, 6-Difluorobenzyl)-1h-1, 2, 3-Triazole Derivatives for Cns Depressant and Anticonvulsant Profile

A series of 1-(2, 6-difluorobenzyl)-1H-1, 2, 3-triazole (5a-d and 7a-d) were synthesized and evaluated for CNS depressant  and anticonvulsant activities by photoactometer, rotarod and pentylene tetrazole induced convulsion method respectively in Swiss albino mice. Diazepam was used as a standard drug. Out of the 8 compounds tested, compounds (5b, 7a and 7b) were showed the CNS depressant activity comparable to that of diazepam at a dose of 5 mg/kg. The active members of the series (5b, 7a and 7b) were selected for anticonvulsant activity study.