Buoyant Drug Delivery Systems: A Comprehensive Review

Novel drug delivery systems are need of recent developments. Controlled drug delivery systems for oral route are widely acceptable and easy to formulate. Oral controlled release systems developed to overcome short comings of conventional controlled released formulations such as short gastric residence time, unpredictable gastric emptying time, unstable at higher pH, site specific absorption, etc. Various approaches have been developed to retain dosage form in stomach for longer period of time. Bioadhesive systems, high density systems, expanding or swelling systems, effervescent buoyant systems has been discovered till date. Drugs those having narrow absorption window in stomach, stable at acidic pH and unstable in the intestinal or colonic pH, having low solubility at higher pH are suitable to develop as buoyant drug delivery systems. Present review focuses on various aspects of buoyant drug delivery systems.