Development and Evaluation of Novel Floating Osmotic Capsule for Zero Order Delivery of Andrographis Paniculata Extract

Andrographis paniculata (Kalmegh, family: Acanthaceae) is used extensively in the Indian traditional system of medicine as a hepato-protective and hepato-stimulative agent. Osmotic drug delivery systems are the best amongst promising strategy based reliable drug delivery systems employed for controlled drug delivery. Floating drug delivery systems is one of the important approaches to achieve gastric retention to obtain sufficient drug bioavailability. Pre-formulation studies are the first step in the rational development of dosage form of a drug substance. Different quantities of cetosteryl alcohol ranging from 50 mg to 200 mg have been checked for floating lag.