Formulation and Evaluation of Sustained Release Matrix Tablets of Venlafaxine Hydrochloride

This study examines the sustained release behaviour of venlafaxine hydrochloride from Hydroxyl propyl methyl cellulose & sodium carboxy methyl cellulose. Venlafaxine hydrochloride is an antidepressant agent. The present research endeavor was directed towards the development of a sustained release dosage form of venlafaxine in the form of tablets to be taken once daily. All lubricated formulations were compressed by direct compression. The compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness and In-vitro dissolution study. Release studies were carried out using USP type 2 apparatus in 900 ml of Distilled Water as dissolution media. Release kinetics were analyzed using zero-order, Higuchi’s square root and Peppa’s exponential equations. All formulations showed compliance with pharmacopoeial standards. Among different formulations F7 showed sustained release of drug for 12 hours with 99.73% of drug release respectively. The regression coefficient value of zero order plots was found to be 0.993. The slope of peppas model was found to be 0.981 for F7.Thus the matrix system of HPMC & SCMC was found to be effective in retarding release of venlafaxine hydrochloride.