Formulation and Evaluation of Phenytoin Loaded Biofilms using Annona Squamosa Biomaterial

In the present paper an effort was made to isolate a biomaterial from the fruit pulp of Annona squamosa and evaluate its film forming capacity. Annona squamosa was isolated by an economic method and subjected to various physical evaluation parameters. The biomaterial was subjected to spectral studies like IR, 1H NMR and DSC analyses. Phenytoin loaded biofilms were prepared using the isolated biomaterial and other co- processing agents. The prepared biofilms were evaluated for their film parameters and subjected to in-vitro drug release studies using static MS diffusion apparatus. The results were compared with the standard HPMC film. The experimental results revealed that the prepared biofilms possessed good folding endurance with appreciable release characteristics. The best film formulation was PS6 with percentage cumulative release of 91.85% over 36 hours. Hence it clearly indicated that the isolated biomaterial possessed inbuilt filmability.