Effect of Meloxicam on the Phrmacokinetics of Pefloxacin and Its Active Metabolite Norfloxacin in Female Goats

A study on pharmacokinetics of pefloxacin and kinetic interaction between pefloxacin (5 mg/kg) and meloxicam (0.5 mg/kg) was carried out through intravenous route in 5 female goats weighing 18-22 kg. A wash out period of 3 weeks was used before each injection. Blood (0.042-48 h) and urine (0.042-72 h) samples were collected. Estimation of pefloxacin and its active metabolite norfloxacin were carried out by using High Performance Liquid chromatography (HPLC). Shorter distribution half life (t1/2 α) of 0.16 h and elimination half life (t1/2 β) of 2.42 h were noted in pefloxacin alone administration and non-significant differences were noted in combination with meloxicam.  Significantly (P