Nitesh Kumar

Psoriasis is a prolonged, immune-mediated inflammatory skin disease. It is characterized by sharply demarcated, red, scaly, coin-sized skin lesions most often on the elbows, hands, knees, scalp and feet. Around 10% of individuals with psoriasis develop arthritis, which may affect the hands, feet, wrists, ankles, neck and lower back. In some cases joints become deformed, causing significant disability. The worldwide prevalence of psoriasis is around 2%, but studies in developed countries have reported higher incidence rates of on average about 4.6%.  In India the prevalence of psoriasis fluctuates from 0.44 to 2.8%, it is two times more common in males compared to females, and most of the patients are in their third or fourth decade at the time of presentation. Nearly two thirds of people with psoriasis have a mild form of the disease, Therefore in most of the cases first line treatment approach is topical. Betamethsone dipropionate (BD) loaded in omega-3- fatty acid fish oil nanoemulsion for the healthier absorption of BD in deeper layer of the skin to stop further progression of inflammatory cycle. For the preparation of nanoemulsion different types of preformulation studies require to perform because every drug has its specific intrinsic chemical and physical property which has been consider before development of pharmaceutical formulation. This property provides the framework for drug's combination with pharmaceutical ingredients in the fabrication of dosage form.

A study on pharmacokinetics of pefloxacin and kinetic interaction between pefloxacin (5 mg/kg) and meloxicam (0.5 mg/kg) was carried out through intravenous route in 5 female goats weighing 18-22 kg. A wash out period of 3 weeks was used before each injection. Blood (0.042-48 h) and urine (0.042-72 h) samples were collected. Estimation of pefloxacin and its active metabolite norfloxacin were carried out by using High Performance Liquid chromatography (HPLC). Shorter distribution half life (t1/2 α) of 0.16 h and elimination half life (t1/2 β) of 2.42 h were noted in pefloxacin alone administration and non-significant differences were noted in combination with meloxicam.  Significantly (P

Nanotechnology received a lot of attention with the never-seen-before enthusiasm because of its future potential that can literally revolutionize each field in which it is being exploited. In drug delivery, nanotechnology is just beginning to make an impact. The multidisciplinary approach of nanotechnology has opened new vistas for the development of nanoscale drug delivery systems to meet the requirements for new drug moieties. These drug moieties can either be integrated into the matrix or attached to the surface of drug delivery particles. The importance of nanotechnology in drug delivery is in the concept and ability to manipulate molecules and supramolecular structures for producing devices with programmed functions. Nanostructures like micelles, liposomes, dendrimers etc. and nanoparticles like solid lipid nanoparticles, polymeric/pegylated nanostructures, metallic nanoparticles etc. have been used to deliver drug at specific sites and reduce side effects on non target organs.