Formulation and Evaluation of Fast Dissolving Famotidine Solid Dispersion Tablet

Fast dissolving tablets are the tablet which dissolves rapidly and shows higher bioavailability than conventional tablets. The concept of formulating Fast dissolving tablets of Famotidine (H2 –receptor antagonist) offer suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability and to know the effects of two synthetic superdisintegrant (Croscarmellose sodium and Sodium starch glycolate). In the present work two methods of solid dispersion were compared for improving the bioavailability i.e. Solvent Evaporation and Fusion method with PVP K30 as a carrier to increase the solubility of the drug. Comparison between these two synthetic superdisintegrant was done by taking different ratios and in combination. Three different combination of these superdisintegrant shows synergistic effect when it is compared to individual. Prepared tablets were subjected to different evaluation parameters such as hardness (2.84±0.15 kg/cm2 to 3.01±0.20 kg/cm2), friability (not more than 0.680±0.0173), weight variation (197.6±1.42 mg to 202.6±1.90 mg), drug content uniformity (97.84±0.35 to 100.23±0.71%), in vitro disintegration time (21.0±0.81 sec to 108.33±0.47 sec), wetting time (29.33±0.47 to 113.33±1.24 sec), in vitro dissolution studies and stability studies are carried out by using the best formulation. From all the formulations prepared and tested, F9 was found to the best formulation.