Synthesis and Antimicrobial Activity of Piperazine Derivatives

Ethyl piperazine is treated with 4- chloro nitrobenzene in presence of anhydrous potassium carbonate and methanol is used as a solvent forms 1 ethyl -4-[4-nitrophenyl] piperazine, then it is treated with iron dust in presence of hydrochloric acid and neutralized with sodium carbonate to form the 4-[4-ethyl piperazine-1-yl] anilline, it is reacted with n-chloro acetyl aryl amine in presence of  anhydrous potassium carbonate forms the final product  1-[2-(aryl amino -2-oxoethyl ) - amino -4-(n-ethyl piperazine)] benzene derivatives were synthesized, the synthesized compounds were screened for their antibacterial activates against s. aures and e.coli by cup plates method . From screening results of some compounds found highly active against both gram – positive and gram – negative bacteria while other compounds possess moderate activity.