Evaluation of Anti-Bacterial Activity of Novel Quinazoline Derivatives

In the present study, a series of novel quinazoline derivatives were synthesized by condensation with different aromatic amines via cyclized intermediate 2-phenyl-1, 3-benzoxazin-4-one.The chemical structures were confirmed by means of IR, H1 NMR. These compounds were screened for anti-bacterial (Staphylococcus aureus ATCC-9144, Escherichia coli ATCC-25922, activities by paper disc diffusion technique. The potency of antibiotic content in samples can be determined by chemical, physical or biological means. An assay was performed to determine the ability of an antibiotic to kill or inhibit the growth of living microorganism. The inhibition of microbial growth under standardized conditions may be utilized for demonstrating the therapeutic efficacy of drugs. Microorganisms employed in biological assay were of various types of bacteria for amino acid & antibiotics, fungi for vitamins & trace elements. The synthesized compounds were evaluated for anti-bacterial activity. Some of these synthesized compounds show significant anti-bacterial activity.