Antinociceptive Activity of different extracts of Leaves of Salvadora Persica L.

Salvadora persica L. (family- Salvadoraceae) is an evergreen small tree commonly known as Pilu, Jal and toothbrush tree. It is used in the treatment of pain, low fever, toothache, nose trouble, piles, scabies, inflammation, scurvy, gonorrhoea, chest disease and boils.  The present study was undertaken to evaluate the antinociceptive activity of the successive extracts (chloroform, ethyl acetate, ethanol and aqueous extracts) of powdered leaves of Salvadora persica L. at the dose of 500 mg/kg b. w. using eddy’s hot plate method. The results of the statistical analysis showed that chloroform and ethyl acetate extracts have significant antinociceptive activity. From the results of antinociceptive effects it can be concluded that the chloroform extract of the powdered leaves of Salvadora persica has shown significant activity (P < 0.05) at 30 min and significant activity (P < 0.01) at 60 and 120 minutes. The ethyl acetate extract has shown significant activity (P < 0.01) at 30, 60 and 120 minutes when compared to the control group. While the standard drug (Morphine Sulphate) shown significant activity (P < 0.01) at 30, 60, 120 and 180 minutes. Other successive extracts (ethanol and aqueous extracts) could not produce the significance of the difference from the control as antinociceptives. Hence present investigation reveals the antinociceptive activity of chloroform and ethyl acetate extracts of leaves of Salvadora persica L Key Words: Salvadora persica L. antinociceptive activity, chloroform and ethyl acetate extracts