Controlled release In Situ forming Ofloxacin Hydrogel for Ophthalmic Drug Delivery

The objective of the present study was to prepare in situ hydrogel for controlled release of ofloxacin using various polymers such as Poloxamer P407, Sodium Alginate and Polyox. In situ were characterized for the Appearance, pH determination, In vitro Gelation studies and viscosity, Rheological studies, Drug Content, In vitro Drug release study, Sterility testing. Drug-excipient compatibility was determined by FTIR. Infrared spectroscopy studies of Ofloxacin, Polyox, Sodium alginate, Poloxamer and HPMC K4M alone and their physical mixture revealed that, Ofloxacin is compatible with all the polymers used. The clarity of the prepared formulations was found satisfactory. The pH of all formulations was found to be satisfactory in the range. The drug content of the prepared formulation was within the acceptable range, and ensures dose uniformity. The curve fitting data revealed that the release followed zero order kinetics.