Mucoadhesive Microemulsion Based Prolonged Release Vaginal Gel for Anti-Fungal Drug

  The objective of the present investigation was to develop and evaluate microemulsion based gel for the vaginal delivery of Sertaconazole. The solubility of Sertaconazole in various oils, surfactants and co-surfactants were checked to identify components of the microemulsion. The ternary diagrams were plotted to identify the area of microemulsion existence. Various gelling agents were evaluated for their potential to gel the Sertaconazole microemulsion without affecting its structure. Carbopol 940 was selected for the formulation of microemulsion based gel. The prepared formulations of Sertaconazole Microemulsion based gel was evaluated by checking its pH, spreadability, rheological studies, mucoadhesive strength, in-vitro drug release studies and ex-vivo retention studies. The Sertaconazole Microemulsion based gel showed good in vitro bioadhesion and anti-fungal activity. The Sertaconazole Microemulsion based gel has potential be successfully used for the topical treatment of vaginal candidiasis.