Formulation and Comparative Evaluation Of Semisolid Dosage Forms Of Natural Agents (Camphor and Menthol) for Muscle Spasms

A muscle spasm, or muscle cramp, is an involuntary contraction of a muscle. Muscle spasms occur suddenly, usually resolve quickly, and are often painful. The use of NSAIDs has been routine in the management of muscle spasm. Although effective at reducing pain and inflammation. NSAIDs may not be appropriate to use frequently or longer time due to their known side effects. Natural agents like camphor and menthol are having analgesic activity as well as each active individual ingredient has its own medicinal value. For greater and effective results, we are using combination of camphor and menthol. Hydrophilic and hydrophobic ointments were prepared by taking 25mg, 50mg and 100mg of each agent as combination of camphor-menthol. All the prepared formulations were evaluated for pH, spreadability and diffusion studies. The selected formulations were evaluated for In-vivo studies in comparison with marketed preparations. The finalized preparation was kept for stability studies according to ICH guidelines. Keywords: In-vivo studies, Natural agents,