Phase Transition Method Use for Preparation of Mouth Dissolving Tablet

Mouth dissolving tablets (MDTs) prepared by the crystalline / phase transition method has focused on decreasing the dissolution (or disintegration) time of the tablets in the mouth, while maintaining sufficiently high mechanical strength to withstand handling during manufacturing, packaging, and transportation. The key to developing a successful MDTs formulation by the phase transition method is to select the right excipients. In general, MDTs are made of highly hydrophilic materials and possess highly porous structures for fast water absorption into the tablet. After heating MDTs, the median pore size of the tablets was increased and tablet hardness was also increased due to phase conversion into the tablets. It is concluded that a combination of low and high melting point sugar alcohols, as well as a phase transition in the manufacturing process, are important for making MDTs without any special apparatus.