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📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

April 2023 Issue 2

Volume 13, Issue 2 - $2023

Volume 13 Issue 2 Cover

Issue Details:

Volume 13 Issue 2
Published:Invalid Date

Editorial: April 2023 Issue 2

Welcome to the 2023 issue of American Journal of PharmTech Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Hemangi J Patel
Editor-in-Chief
American Journal of PharmTech Research

Articles in This Issue

Showing 5 of 5 articles
Research PaperID: AJPTR132001

Quality Assurance Of Drug Information Services Provided In A Tertiary Care Hospital In Calicut

Arun Krishna A, Sahla, Ashna, Siraj Sundaran

Drug information service provides accurate, relevant and unbiased information on drugs and any aspects related to drugs. The objective of this study was to conduct the quality assurance of drug information service provided. The study was conducted for a period of six months in the drug information centre of a tertiary care hospital in Calicut. Quality assurance was done on the basis of modified systematic approach. A total of 45 drug information queries were received in the drug information center during the study period. Among the queries majority were from pharmacy (77.78%) and nursing station (22.22%). A checklist on basis of modified systematic approach was used to verify the quality. In the queries collected 85% enquirer’s details was relevant enough and 15% were incomplete. Drug information response had a professional style in 70% and whereas 30% were not having standard presentation such as alignment or spacing, etc. Among the 20 of the drug information collected for evaluation 90% had relevant information for the query and remaining 10% needed more details. In the source of references given in the response 60% were partial and 40% were incomplete. Based on the time taken for response 55% was timely given and 45% took more time than it really required. The documentation procedure was complete and perfect in all case. Study concluded that although drug information service is actively performed the quality of service has to be upgraded. Standard operating procedure has to be framed and revised as per the lacunas found.

Quality AssuranceDrug Information Service.
334,435 views
100,417 downloads
DOI:
DOI: 10.5281/zenodo.7878347

Contributors:

 Arun Krishna A
,
 Sahla
,
 Ashna
,
 Siraj Sundaran
Research PaperID: AJPTR132002

Evaluation of Modified Gum From Pistacia Lantiscus As A Release Retardant Matrix In The Tablet Dosage Form

Tushar D. Fegade, Vijay R. Patil, Tushar A. Deshmukh

In the current investigation we formulated and evaluates matrix tablet using modified gum of Pistacia lantiscus gum (PLMG) as natural matrix forming agent used in various successively increasing concentration. The pre-compression study of the powder blends of drug, PLMG and other excipients were done by calculating bulk density, tapped density, angle of repose and carr’s index (% compressibility) and hausner’s ratio. The tablets using PLMG as matrix forming agent were prepared by direct compression method and prepared tablets were evaluated for thickness, hardness, weight uniformity, friability and content uniformity and were found according to the official guidelines by pharmacopoeia. The swelling behavior of prepared matrix tablets was studied using for 12 hours at 37 ±0.2 0C, it was fond that the drug to modified gum ratio of 1:2 was found to be optimum swelling with the sustained release of model drug up to 97.12 in matrix tablet formulation. The results revealed, that modified fraction of Pistacia lantiscus gum can be used as a drug release modifier to delay as the rate of drug release of which depended on the amount of gum composition, as the concentration of gum was increased there was sustain the drug release.

Pistacia lantiscustabletmodified gumdiclofenac potassiumhausner’s ratio.
334,760 views
100,474 downloads
DOI:
10.5281/zenodo.7878365

Contributors:

 Tushar D. Fegade
,
 Vijay R. Patil
,
 Tushar A. Deshmukh
Research PaperID: AJPTR132003

Anti-Ulcer Tablet of Pantoprazole: A Brief Review Of Its Pharmacological Properties and Therapeutic Uses with Respect To Effervescent Tablets

Dhivakaran A¹, Gomathi M, Shamini S, Priyanga G

Peptic ulcer is a common gastrointestinal disease seen among many peoples. It may be caused by irregular food habits, spicy foods, either an infection or long-time use of medications, drugs and stress. An ulcer depends upon the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defences. A number of anti-ulcer drug are available for curing ulcer disease. Standard treatment is including antibiotics and proton pump inhibitors. But the same time these drugs are expensive and there are many side effects caused by these drugs comparing to other herbal medicines. Pantoprazole is an irreversible proton pump inhibitor (PPI) that reduces gastric acid secretion. It is used to treat stomach ulcers, gastro-oesophageal reflux disease (GORD), acid reflux, and heartburn. Zollinger-Ellison syndrome is a rare disorder brought on by a pancreatic or intestinal tumour that is treated with pantoprazole. Both a generic and a brand-name version of the oral tablet medication pantoprazole are offered. A stomach H+/K+-ATPase (hydrogen-potassium adenosine triphosphatase) inhibitor is pantoprazole. Although oral dose forms are the most common drug, they nevertheless have significant drawbacks compared to other delivery systems, such as the possibility of medication absorption that is too sluggish and complicated by gastric residence time. It can be treated by using a lesser dosage of the medication instead of taking it in liquid form. Another technique is the effervescent technique, which can be used to create a dosage form that can speed up the time the drug dissolves and combines with the body. This technique is typically employed with preparations for rapid release. Effervescent tablets are being used more frequently and widely to modify the behaviour of drug release, such as in sustained and controlled release preparations, pulsatilla drug delivery systems, and so forth, along with the development of novel pharmaceutical techniques. The present review illustrated about the etiology of peptic ulcer, its complications, pharmacological property of pantoprazole antiulcer drug and the new effervescent tablet methodology.

Peptic ulcerPantoprazoleProton pump inhibitorFloating Delivery SystemEffervescent Tablet
334,608 views
100,472 downloads
DOI:
10.5281/zenodo.7878369

Contributors:

 Dhivakaran A¹
,
 Gomathi M
,
 Shamini S
,
 Priyanga G
Research PaperID: AJPTR132004

Evaluation of Antiulcer Activity of Piper Chaba Leaves Extract Against Indomethacin Induced Gastric Ulcer In Experimental Animals

Shruti Jain, Jyoti Menaria

The Piper chaba ethanolic extract showed protection against characteristic lesions produced by ulcer due to Indomethacin administration. This gastroprotective effect of Piper chaba ethanolic extract may be due to both reductions in gastric acid secretion and gastric cytoprotection which may further contribute in the treatment of peptic ulcers. Indomethacin produces necrotic lesions in the gastric mucosa by reducing the secretion of bicarbonate and production of mucus, increasing vascular permeability and decreasing non-protein sulfhydryl groups of gastric mucosa. Indomethacin rapidly penetrates the gastric mucosa apparently causing cell and plasma membrane damage leading to increased intracellular membrane permeability to sodium and water and thus causing gastric mucosa damage. Suppression of prostaglandins synthesis by ethanol results in increase susceptibility of the stomach to mucosal injury and gastro duodenal ulceration. The Piper chaba ethanolic extract significantly reduced ulcer index. The Piper chaba ethanolic extract showed protection against characteristic lesions produced by ulcer due to Indomethacin administration. This gastroprotective effect of Piper chaba ethanolic extract may be due to both reductions in gastric acid secretion and gastric cytoprotection which may further contribute in the treatment of peptic ulcers.

AntiulcerIndomethacinWistar RatsPiper ChabaEthanolic Extract.
334,598 views
100,440 downloads
DOI:
10.5281/zenodo.7878391

Contributors:

 Shruti Jain
,
 Jyoti Menaria
Research PaperID: AJPTR132005

Management of post- stroke disability in Unani Medicine – An open interventional clinical trial

Md. Izhar Alam, Abdul Nasir Ansari, Md. Tanwir Alam

An open, before and post without control, interventional clinical trial was used to conduct the investigation. The length of the study was set at 30 days. Nuskha Maulusool was administered in decoction form once per morning (empty stomach) for 15 days to thirty qualified patients with hemiplegia brought on by a stroke. On the 13th and 15th days, Nuskha Mushile Balgham was combined with Maulusool and administered orally to induce purgation. Inkebab was introduced with 20 gms of marzanjosh on the 16th day and continued every day until the study's conclusion. To evaluate the individuals' activities of daily living (ADL), the before and post treatment values of the Barthel index were compared using a paired t test. After receiving treatment, patients' ADL significantly improved (p 0.001). Throughout and after the research, no unpleasant side effects were noticed in the treatment group, and overall treatment compliance was satisfactory. The study found that the test medication improved patients' ADLs in a statistically meaningful way.

Unani MedicineHemiplegiaADLInkebabFalije NisfiMunzij Mushil
335,124 views
100,483 downloads

Contributors:

 Md. Izhar Alam
,
 Abdul Nasir Ansari
,
 Md. Tanwir Alam

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