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American Journal of PharmTech Research

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

August 2022 Issue 4

Volume 12, Issue 4 - $2022

Volume 12 Issue 4 Cover

Issue Details:

Volume 12 Issue 4
Published:Invalid Date

Editorial: August 2022 Issue 4

Welcome to the 2022 issue of American Journal of PharmTech Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Hemangi J Patel
Editor-in-Chief
American Journal of PharmTech Research

Articles in This Issue

Showing 8 of 8 articles
Research PaperID: AJPTR124001

Benzodiazepines Use and Its Risk Of Falls In The Elderly: A Review

Lincy George, Erin Xavier, Irien M George, Jesteena Jacob

Falls are the major cause of morbidity and mortality among the elderly. Falls are caused by a combination of factors. Most of these falls are caused by intricate interactions between environmental and internal causes. The use of benzodiazepines is linked to a high proportion of falls among older people. Benzodiazepines are a class of drugs that can treat a range of conditions. Doctors often prescribe them to treat anxiety, seizures, and insomnia. The short-term use of these medications is usually safe and effective, but long-term use can lead to tolerance, dependence, and other adverse effects. After falls, older people frequently experience a loss in functional status and social activities, as well as a lower quality of life. Therefore, they should be provided to elderly patients under the current clinical standards and reviewed on a regular basis. The therapy of choice should be short-acting benzodiazepines in the elderly population. It should be given as a short-term treatment and gradually tapered thereafter. Benzodiazepines should be replaced with safer alternatives such as sleep restriction therapy, cognitive behavioural therapy, and sleep hygiene psychoeducation. In this article, we examine the evidence on the prevalence of benzodiazepine usage and drug dependence, as well as the fall risk of benzodiazepines in the elderly.

Benzodiazepine useOlder peopledrug dependenceadverse effectsfall riskdrug withdrawal.
330,503 views
99,106 downloads

Contributors:

 Lincy George
,
 Erin Xavier
,
 Irien M George
,
 Jesteena Jacob
Research PaperID: AJPTR124002

Formulation and evaluation of microemulsion gel containing Boswellia serrata and Primrose oil for Arthritis

Shyam Rathod, Nayan Gulhane, Harita Desai

Osteoarthritis and rheumatoid arthritis are two inflammatory joint conditions that lead to degeneration of the synovial region leading to pain and deterioration of the joints finally culminating into loss of joint function. Natural herbal extracts like Boswellia serrata have been found to contain components like Boswellic acids which exhibit the property of inhibition of certain enzymes which are mediators of inflammation in the tissue region. These active components aid to inhibit enzymes like 5-Lipoxygenase (5-LO) and 5-Hydroxyeicosatetraenoic acid (5-HETE) thus inhibiting the inflammation component of joint damage. The poor aqueous solubility of the extract of Boswellia serrata poses a challenge for designing effective dosage forms for administering the boswellic acid enriched extract to the site of action. The present work comprises of formulation of a clear isotropic microemulsion system and microemulsion gel containing solubilized Boswellia serrata extract and Primrose oil. The microemulsion was evaluated for globule size, Fourier transform infrared spectroscopy, entrapment efficiency, stability and irritation potential by HETCAM assay whereas the microemulsion gel was evaluated for pH, viscosity and irritation potential. The microemulsion was found to exhibit a globule size of 403.1 nm,  no changes in chemical structure, entrapment efficiency of 91 % and stable at all conditions of temperatures of 25°C,  30°C  and 40°C, light, freeze-thaw, centrifugation test and non-irritant in nature. The microemulsion gel was found to have a pH of 5.5, viscosity of and non-irritant by HETCAM assay.

microemulsionosteoarthritisinflammationHETCAMentrapment efficiencyboswellic acid
330,328 views
99,237 downloads

Contributors:

 Shyam Rathod
,
 Nayan Gulhane
,
 Harita Desai
Research PaperID: AJPTR124003

Review on the Origin, Transmission and Clinical Therapies of Covid-19

Mayuri V. Bhosale, Abhishek V. Desai, Mayuri S. Bhadalekar, Vinayak R. Rohile, N. B. Chougule, N. R. Inamdar

In December 2019, Wuhan, Hubei Province, China, reported an outbreak of pneumonia of unknown cause. The Huanan Seafood Wholesale Market was found to be associated with instances of pneumonia. Inoculation of respiratory materials into human airway epithelial cells, Vero E6 and Huh7 cell lines, resulted in the isolation of a novel respiratory virus, which was later identified as a novel coronavirus linked to SARS-CoV after genome analysis (SARS-CoV-2). The beta coronavirus SARS-CoV-2 belongs to the Sarbecovirus subgenus.1 Corona virus causes pneumonia, colds, sneezing, and coughing in humans, while it causes diarrhoea and upper respiratory infections in animals. Corona virus spread from person to person or animal to animal through airborne droplets. Corona virus enters human cells via the ACE-2 exopeptidase receptor on the cell membrane. WHO and ECDC recommended avoiding public places and close contact with infected people and pets.

SARS-CoV-2Immunoglobulin GRT-PCRPharmaceuticalsNutraceuticals
330,409 views
99,268 downloads

Contributors:

 Mayuri V. Bhosale
,
 Abhishek V. Desai
,
 Mayuri S. Bhadalekar
,
 Vinayak R. Rohile
,
 N. B. Chougule
,
 N. R. Inamdar
Research PaperID: AJPTR124004

Phytochemical and Biochemical Studies Of Medicinal Plant Bacopa Monnieri

Priyanka Shanmugam, Kanimozhi Rajendran, Murugesan Madhesh, Madhesh Murugan

Screening of phytochemicals is a precious stair in the detection of bioactive principles present in particular medicinal plant and may lead to novel drug discovery. In the present study, Bacopa monnieri root extracts are tested for phytochemical and biochemical studies. Ethanolic extract shown good number of compounds compared to methanolic, ethyl acetate, aqueous and chloroform extracts. Phytochemical analysis of ethanolic tuber extract of Bacopa monnieri has shown the biological compounds like carbohydrates, cholesterol, Amino acids, Steroids, Alkaloids, Flavonoids, Cardiac glycosides, Saponins, Tannins, Terpenoids, Phlobatinins, Fattyacids, Coumarins and Phenols. The result suggests that the phytochemicals present in Bacopa monnieri tuber extracts may show antimicrobial, anti-inflammatory and antioxidant properties.

Bacopa monnieriPhytochemicalSolvent extractionBiochemical studies.
330,410 views
99,283 downloads

Contributors:

 Priyanka Shanmugam
,
 Kanimozhi Rajendran
,
 Murugesan Madhesh
,
 Madhesh Murugan
Research PaperID: AJPTR124005

Quantitative Determination of Trace Levels of Nitromethane and Its Analog Impurities by Using HS-GC-MS

Siva Krishna Nachaka, Ramesh Babu Kodavati, Gopal Vaidyanathan, Sattibabu Paila, Narmada Palnati

A specific HS-GC-MS method has been developed, optimized and validated for the determination of five genotoxic impurities namely Nitromethane, Nitroethane, 2-Nitropropane, 1-Nitropropane and 1-Nitrobutane in TRB-G, intermediate of Trabectedin drug substance. Chromatographic separation of five genotoxic impurities was achieved on Capillary GC column (Rtx-1701. Fused silica capillary column; 30 m length; 0.25mm internal diameter. coated with 14% Cyanopropylphenyl and 86% dimethyl polysiloxane stationary phase of 1.0 µm film thickness) and passing helium carrier gas with Electron Impact ionization (EI) in Selective Ion Monitoring (SIM). The mass fragments (m/z) were selected for the quantification of m/z-30 for Nitromethane, m/z-29 for Nitroethane, m/z-43 for 2-Nitropropane and 1-Nitropropane and m/z-57 for 1-Nitrobutane. The performance of the method was assessed by evaluating the specificity, linearity, sensitivity, precision and accuracy experiments. The established limit of detection values for the genotoxic impurities were in the range of 0.25 µg/g – 0.58 µg/g and limit of quantification values were in the range of 0.75 µg/g – 1.75 µg/g. This developed method was found to be linear with correlation coefficient is greater than 0.999. The average recoveries for the accuracy were in the range of 89.4–106.8%. Developmental and validation experiments were discussed in detail in this paper.

Trabectedin (TRB)HS-GC-MSGenotoxic impurities and Method validation.
330,846 views
99,202 downloads

Contributors:

 Siva Krishna Nachaka
,
 Ramesh Babu Kodavati
,
 Gopal Vaidyanathan
,
 Sattibabu Paila
,
 Narmada Palnati
Research PaperID: AJPTR124006

Barriers involved in Intravenous to Oral Antimicrobial Conversion Therapy and their rectifiable methods: A Review

Sneha Jacob, Pavana Mathai, Priyanka P V, Happy Thomas

Barriers to an early antimicrobial conversion from parenteral to non-parenteral routes are an important problem in the current scenario. Barriers such as a lack of appropriate guidelines for conversion therapies, a lack of culture sensitivity tests for selecting sensitive antibiotics, a lack of supervision by healthcare professionals on converted regimens, a lack of awareness among the patient population about the effectiveness of conversion therapy, and a lack of oral variant antibiotics for its intravenous agents on the market must be identified and resolved. The majority of barriers could be resolved by means of educational, interventional, and structural organizational changes. This may reduce the duration of parenteral antibiotic therapy and the consequent length of stay in hospital. This article review focuses on barriers involved in intravenous to oral antimicrobial conversion therapy and their rectifiable methods. Antibiotics are the most powerful weapons for infectious diseases and could be used in the most appropriate manner by resolving the barriers involved in such conversion therapies and improving the quality of life.

Intravenous (IV)AntibioticParenteralNon-parenteral.
330,887 views
99,333 downloads

Contributors:

 Sneha Jacob
,
 Pavana Mathai
,
 Priyanka P V
,
 Happy Thomas
Research PaperID: AJPTR124007

A Review Novel on Synthesis of Triazole and Chemistry of Active Chemical Moiety

Soubin Roy, Santosh Dattu Navale, Sumit Shivaji Misal

The triazoles possess wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the basic developments in synthesis and biological activities of triazole derivatives. The novel chemical moiety used in medicinal active substance either (R) or (L) hence Dextro or Levo rotatory form. The broad spectrum of activity is due nitrogen hence nitrogen containing loan pair of electron transfer to another substance and formation of covalent bond.

Pharmacological activityTriazoleSynthesisIsomersBio conjugation
330,967 views
99,410 downloads

Contributors:

 Soubin Roy
,
 Santosh Dattu Navale
,
 Sumit Shivaji Misal
Research PaperID: AJPTR124008

Review On Nephroprotective Activity of Medicinal Plants On Drug-Induced Nephrotoxicity

Gurnoor Suman, Nallagatla Srihala, V.V. Rajesham, T. Rama Rao

The excess use of drugs for various ailments is resulting in increasing cases of drug-induced nephrotoxicity. Acute kidney injury is the most common type of drug-induced nephrotoxicity, which accounts for 85% of cases of nephrotoxicity. Herbal medications, due to the presence of various phytoconstituents, possess nephroprotective activity and are used in the treatment of kidney disorders like acute kidney injury, nephrotic syndrome, chronic interstitial nephritis, etc. The present review aimed to elucidate the list of medicinal plants which are scientifically proven to have nephroprotective activity against drug-induced nephrotoxicity. 

NephrotoxicityNephroprotective activityGentamicin-induced nephrotoxicityMedicinal plants.
331,177 views
99,312 downloads

Contributors:

 Gurnoor Suman
,
 Nallagatla Srihala
,
 V.V. Rajesham
,
 T. Rama Rao
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