Yogendra Singh

The main objective of the study is to measure the appropriateness of antibiotic prescription for urinary tract infections in several general hospitals and to evaluate the quality of antibiotic prescription among these services. For this study a cross-sectional study was carried out in the various hospitals from different hospitals of north India. The patients were analyzed between the age group of 15-45 years. The main variables of the study were: type of urinary infection, hospital admission, antibiotic prescription, either the presence of one or more disorders and urine culture request. A panel of experts, established first-choice, second-choice and inappropriate antibiotic treatments for each type of urinary tract infection, based on the available scientific evidence. A total of 8500 patients were analyzed from acute urinary tract infected. Out of which 81-83% were lower urinary tract infected patients. The most commonly used antibiotics in hospitals were ciprofloxacin and Amoxicillin clavulinate. The percentages of first-choice, alternative-choice and inappropriate antibiotic prescriptions were: 43%, 44% and 14% respectively. This paper describes the first choice of drugs prescribed by the doctors. We observed a significant variability in appropriateness of antibiotic prescriptions among the participating centers (p < 0.001).

The present study aimed at development and evaluation oral fast dissolving film of Salbutamol Sulphate utilizing HPMC as a film forming polymer and PEG 1000 as a plasticizer. Response Surface Methodology was used to optimize the oral fast dissolving film formulation. In the design, concentration of HPMC and concentration of PEG 1000 was selected as independent variable. Tensile strength, elongation at break and elastic modulas was selected as dependent variable. The results of the study demonstrated a successful development of a film with optimum mechanical property and disintegration time. The adopted design was very much successful as an optimization tool in this present study. The optimized formulation was evaluated by SEM & FTIR and the results were found appropriate. The accelerated stability study indicated the stability of the optimized formulation up to 6 month. In the conclusion, it is advocated that the development of optimized oral fast dissolving film formulation was successful. Key words: Plasticizer, Oral Fast Dissolving Film, Factorial Design, Elongation at break