Yashwant

The potential of guar gum as a film coating material for colon targeted delivery of raupyabhasma is assessed in this study. The granules was prepared by mixing raupyabhasma, guar gum and xanthan gum which was coated by guar gum and pH-sensitive polymer eudragit FS30D sequentially around drug-loaded granules. The outer eudragit FS30D coating defends the system against gastrointestinal environment and dissolves rapidly in distal small intestine, where a lumen pH of over 7 triggers the dissolution of the enteric polymer. The inner guar gum coating works as a time-controlled retardant and offers additional protection of the granules until it is degraded by microbes at the proximal colon. In vitro results indicate that guar gum followed by eudragit FS30D coating is a feasible coating material to achieve colon specific drug delivery.

  This community based study assessed the prevalence of obesity and associated factors among age group between 16 to 75 years. The obese and overweight subjects were from age group from 31 to 45 year which was 42.42% and 28.78% respectively and most of them were in sedentary jobs. Obese and overweight dipsomaniac smokers were from the age group46-60 year which was 90%. Prevalence of hypertension and diabetes among overweight elderly was observed in this study. Key words: Obesity, Overweight, Dipsomaniac, Hypertension, Diabetes