Varsha S. Zade

Formamidines, Thiazoles, dithiazolidines, thiadiazines and other ring system derivatives have a long history of applications in pharmaceutical and agrochemical industries. Our interest in the chemistry of the formamidine  nucleus and its derivatives prompted us to explore the synthesis of 1-hepta-O-acetyl- β-D-lactopyranosyl-3-H/Aryl formamidines, N-hepta-O-acetyl- β-D-lactopyranosyl-N’-benzothiozolyl formamidines and N-hepta-O-acetyl-β-D–lactopyranosyl formimidic acid alkyl esters by reductive desulphurization of 1-hepta-O-acetyl- β-D–lactopyranosyl–H / aryl thiocarbamides, 1-hepta-O-acetyl-β-D-lactopyranosyl-3-[2-N-substituted benzothiazolyl] thiocarbamides and 1-hepta-O-acetyl-β-D–lactopyranosyl-O-alkyl thiocarbamates respectively using Raney Nickel. The identities of these newly synthesized derivatives have been established on the basis of chemical transformations and IR, 1H NMR and Mass spectral studies. The title compounds have been assayed for their biological activity against gram-positive as well as gram negative microorganisms. These compounds show most promising activity towards these micro-organisms.

Carbohydrate science has been extensively studied and many excellent reviews are available. N and S-linked derivatives of various sugars have received a great attention because of their vital role in several biological processes. Ureas, thioureas and their derivatives have strong antibacterial, antitumor activities. They also play an important role in organic synthesis as intermediates. This considerable attention has been directed towards the synthesis of various thiomaltosides. A series of S-hepta-O-acetyl maltosyl-1-aryl dithiocarbamates have been synthesized by the interaction of hepta-O-acetyl maltosyl bromide and various ammonium aryl dithiocarbamates in isopropanolic medium. The newly synthesized compounds have been characterized by analytical and IR, 1H NMR and Mass spectral analysis. The polarimetric study of the compounds has been carried out. Antibacterial and antifungal activities of these compounds were determined on E. coli, S. aureus, Ps. aeruginosa, S. typhi, R. oligosporus and A. niger. These compounds show appreciable activity towards these microorganisms.