V. Anandhan

  The main objective of the present investigation is to evaluate the analgesic activity of methanolic extract of Nibea maculata and Johnius dussumieri on mice. Analgesic activity of methanolic extract of Nibea maculata and Johnius dussumieri at a dose of 50 mg/Kg and 100 mg /Kg were evaluated against drug pentazocine at a dose of 5 mg/Kg. Adult Swiss albino mice of either sex of six numbers in each group were under taken for study and evaluated by tail flick and tail immersion method. The both doses of Nibea maculata crude methanolic extract and Johnius dussumieri crude methanolic extract were found to produce significant (P

  Fishes have some pronounced pharmacological activities or other properties which are useful in the biomedical area. In the present study crude methanol extracts from 4 species of sciaenidae (Johinus dussumeri, Kathala axillaris, Nibea maculate and Johnius trachy cephalus), Puducherry Coastal Area  were tested against five bacterial pathogens and one fungal pathogens. In bacterial activity the maximum inhibition zone 12mm was observed from Johinus dussumeri methanol extract against (Klebsiella pneumoniae). In antifungal activity maximum inhibition zone 6mm was noted from methanol extract of Nibea maculate against Candida albicans. Out the four species tested only one Nibea maculata has antifungal activity. This shows that fishes extremely strange to the fungal contact and its mediated infection. The antimicrobial property of the sciaenidae fish extracts reveals that they are low enough to bring the effect against pathogens. It may due to the incidence of bacterial presence in their habitat induce the fish to produce the antimicrobial compounds. Meager antimicrobial effect towards fungus may be of due to their rare presence in their habitat. The negative activity of other species could be attributed to the unsuitability of the method of extraction to the antibacterial screening.