Sudarshan Ramachandran

Dubowitz syndrome is a genetic and chromosomal instability disorder characterized by growth hormone deficiency or defects in the cholesterol biosynthetic pathway. It is characterized by retarded growth, several craniofacial manifestations, skin eruption, soft-tissue syndactyly, central nervous system and oral manifestations. There are reports of even malignant tumors associated with this syndrome. This manuscript reviews the manifestations and management of the dubowitz syndrome.