Shashikant Sudarshan Upadhye

The Improvement in the nanotechnology brings revolutionary changes & helps in preparing the novel formulations. The proniosomes are solid colloidal particles which may be hydrated immediately before use to yield the aqueous niosome dispersions similar to those that are produced by more cumbersome conventional methods. These proniosomes minimize the problems of niosome physical stability such as leaking, aggregation & fusion provide additional convenience in dosing, transportation, storage & distribution. The proniosomes overcome the disadvantages involved with liposomal & niosomal drug delivery systems. This review focuses on different aspects of proniosome such as components , types, preparation, evaluation & applications.

The oral route of drug delivery is most preferred route of drug delivery due to its various advantages like patient compliance, ease of administration. But it has some drawbacks like non site specificity. To overcome this drawback gastroretentive drug delivery system is used. To understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. This review also includes different approaches for Gastroretentive drug delivery system i.e. floating drug dosage systems, swelling or expanding systems, high density system, mucoadhesive systems, Magnetic systems, raft forming system, evaluation tests, advantages, disadvantages, future prospects, different marketed preparations.