Saripadiya Nimesh D

Skin cancer remains the second most common cancer causing death in majority of the population worldwide.” Chemotherapeutical treatment generally includes treatment by administration of chemotherapeutical formulations mostly by intravenous route of administration which is painful, toxic, time consuming and costly for the patients. Chemotherapy also causes toxicity and cell death to other normal cells in the body apart from cancerous cells. The aim of the present investigation was to formulate a topical nano-particulate drug delivery system which causes lower exposure to normal body cells by higher efficacy of targeting the cancerous cells, producing lower toxicity rates and avoiding maximum possible side effects.” “Henceforth, an anti-neoplastic agent has been used in order to prepare Nano-structured Lipid Carriers (NLCs) which was further loaded into gel formulation for topical application. “The nano-structured lipid carrier (NLCs) of 5-fluorouracil (5-FU) were prepared by using Compritol ATO 888 by double emulsification method.” The lipids were selected based on the solubility studies and partition coefficient of 5-FU in lipids. The particle size of optimized formulation was found to be 246.2nm. The in vitro release studies of developed NLCs was carriers carried out at pH 7.4. Sodium carboxy methylcellulose, hydroxyl propyl methyl cellulose , and chitosan hydrogels loaded with NLCs were developed. The permeability behavior through dialysis membrane was performed for 24 hrs and Q 24 of optimized gel formulation was found to be 435.974µg/cm2.The steady-state flux (Jss) was found to be 0.062102 mg/cm2 , and permeability coefficient (Kp) was found to be 4.14013 cm/hr for optimized NLCs based gel  formulation  for ex-vivo skin permeability studies. Keywords: Nano-structured lipid carrier (NLCs), Steady-state flux, Permeability coefficient

Abuse and misuse of prescription opioids is a significant public health concern. The  strategies used to confer abuse-deterrent properties on opioid abuse deterrent formulations (ADFs). The objective of this study was to develop techniques for an abuse deterrent (AD) platform utilizing the Granurex process. For the preparation of abuse deterrent extended release formulation core material was layered with dry active pharmaceutical ingredient with the help of Granurex technology and after the drug layering suitable polymeric coat was applied to make formulation crushed resistance and resistance to dose dumping. Formulation optimization was accomplished by utilizing full factorial design of experiments to determine the effect of the three formulation factors: Ethyl cellulose 45 cps, white wax and carbopol 974P NF; each of which was studied at three levels on crushed resistance (CR) attributes of the produced extended release pellets. Suitable formulation ingredients were employed as carrier matrices and processing aids. All of the formulations were evaluated for the crushed resistance and dose dumping  attributes, such as crushing strength, extraction studies of drug in different levels of solvents and particle size . All of the design of experiments formulations demonstrated sufficient hardness and elasticity, and could not be reduced into fine particles , which is a desirable feature to prevent snorting. In addition, all of the formulations exhibited good gelling tendency in water with minimal extraction of drug in the aqueous medium. Moreover, Carbopol 974P NF, in combination with white wax, could be utilized to produce pellets with crushed resistance potential. Granurex has been demonstrated to be a viable technique with a potential of develop novel AD formulations. Keywords: Abuse deterrent formulations, Crushed resistance