Sameer S

Bronchiolitis is a common lung infection in young children and infants. It causes inflammation and congestion in the small airways (bronchioles) of the lung. Bronchiolitis is almost caused by a virus. Bronchodilators are medication which makes breathing easier by relaxing the muscles in the lungs and widening airways. To assess the efficacy and risk associated with the use of bronchodilators in pediatric patients with bronchiolitis.  To assess the Efficacy of Bronchodilators, to evaluate the risk associated with bronchodilators in bronchiolitis patients and to evaluate the patient compliance in patients using bronchodilator for bronchiolitis. This study was conducted in 10 bronchiolitic pediatric patients. This study was conducted by categorizing the patients according to their Respiratory Rate, SpO2 and Heart Rate values. Patient compliance is analyzed using CRS scale and risk is assessed with Wang Scale.

The Mouth Dissolving Drug Delivery Systems was an advancement that came into existence in the early 1970’s and combats over the use of the conventional tablets, syrups, capsules which are the other oral drug delivery systems. Orally disintegrating dosage forms can address the pharmaceutical needs of the paediatric and geriatric patient group having difficulties in swallowing the conventional solid oral dosage forms. Orally disintegrating dosage forms also have the advantage of self medication, pain avoidance hence better patient compliance. Taste masking of bitter drugs is an important parameter. Orally disintegrating dosage forms may have an added advantage of bypassing first pass metabolism. Acyclovir is an antiviral drug used for the treatment of herpes simplex virus (HSV), mainly HSV-1 and HSV-2 and varicella zoster virus. It is a BCS class III drug. Hence an orally disintegrating tablet formulation of acyclovir was prepared by direct compression techniques after incorporating superdisintegrants croscarmellose sodium , sodium starch glycolate and Crossprovidone . Eight formulations were prepared. Tablet containing sodium starch glycolate and croscarmellose sodium showed excellent in vitro dispersion time and drug release as compared to other formulation. After   study of eight formulations F8 showed short dispersion time with maximum drug release in 25 min. It is concluded that fast disintegrating acyclovir tablets could be prepared by direct compression using superdisintegrants.

Osmotic systems use the principle of osmosis as delivery force to deliver the drug from the system, and the release rate is unaffected by the body’s pH and other physiological and gastrointestinal factors. Osmotic tablet of lornoxicam is prepared successfully to deliver drug in controlled release form for once day therapy in arthritis by overcoming all the side effect and enhancing bioavailability. The objective of the present work was to design osmotically driven oral drug delivery system containing Lornoxicam as an active ingredient and evaluate the effect of various membranes( microporous and semipermiable) on release of drug from osmotic tablet. Core tablet of lornoxicam is prepared, coated with cellulose acetate (39.8 D.S.) in which batch 6b (semipermiable) give the maximum of 91.04% release from osmotic tablet of lornoxicam in control passion as compare to other(microporous membrane coated batches.