S.E.Bhandarkar

9,10-Bicyclo-3-substituted-pyrazine-2-(1H)-one was prepared by mixing substituted  aromatic diamine and 2-oxo-2-substituteted acetic  acid in aq. HCl and then stirred at 400Cfor 4 hrs. Progress of the reaction by the formation of thick solid & it was monitored  by TLC ( ethyl acetate /Hexane ,1:1) After the completion of the reaction, the solid product was filtered, washed with the water and dried .The crude product was purified by dissolving in hot aqueous NaOH followed by neutralization with acetic acid. The isolated product was recrystalised from  methyl isobutyl ketone. The compounds thus synthesized have been characterized by physical and spectral data. All of these titled synthesized compounds have been screened for antimicrobial study and  are found to possesses excellent antimicrobial activities.

1-(4- chloro -1-hydroxynaphthalen-2-yl)-ethanone were prepared by refluxing 4- chloro -naphthalen-1-ol with  glacial acetic acid in presence of fused ZnCl2 then 1-(4- chloro -1-hydroxynaphthalen-2yl)-2-aryl-prop-2-en-1-one were synthesized  from  1-(4- chloro -1-hydroxynaphthalen-2-yl)-ethanones by condensing it with aromatic aldehydes. 1-(4- chloro -1-hydroxy-naphthalen-2-yl)-3-aryl-prop-2-en-1-ones, urea and concentrated HCl in DMF were added and refluxed. Cool & pour in crushed ice, it was then treated with cold NH4OH solution to get titled compounds. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. All of these titled synthesized compounds are found to posses excellent antimicrobial activities.