Roshan.S

Abutilon indicum Linn. (Malvaceae) commonly called Country Mallow is abundantly found as weed in sub-Himalayan tract and in hotter parts of India. The present study attempts to summarize the pharmacognostical profile of Abutilon indicum Linn. The study comprises of preliminary phytochemical screening, morphology, and histology.

The aim of the present study is to enhance solubility of simvastatin by solid dispersion technique. Solid dispersions were prepared by fusion method by using various polymers. Formulation is optimized on the basis of acceptable solid dispersion properties and in-vitro release. In order to obtained best optimized product, 5 different formulations were developed. Different polymers like PEG 6000, HPMC 6000,HPC 1000 were taken as variables. Angle of repose, carr’s index, particle size, drug content and dissolution study were studied as response variables. The different physical properties showed best comparable results with drug. But higher percentage of drug release was observed when the formulation contained PEG6000 in 1:1.5 ratio (f5) compared to other formulations. Form this study it concluded that formulation (f5) which contained PEG (1:1.5) as polymer showed best dissolution profile compared to the drug. The formulation contained PEG 6000 was selected as optimized product.

Plants produce a diverse range of bioactive molecules, making them a rich source of different types of medicines. A regular and widespread use of herbs throughout the world has increased serious concern over their quality, safety and efficacy. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of herbal health claims. In the present study, we examined the antioxidant effects of Terminalia Catappa plant extract. Dried and powered of T. Catappa was extracted with hexane, chloroform, methanol, ethanol and water. Total phenolic and flavonoid contents of different solvent extracts were determined. Of the different solvent extracts, methanol extract had the highest phenol and flavonoid content of 121.9±3.1mg/g and 59.6±1.5mg/g respectively. Antioxidant assays were carried out by using different in vitro models such as total reducing power, total antioxidant activity, lipid peroxidation inhibitory activity, DPPH radical scavenging activity and superoxide radical scavenging activity. methanol extract showed the highest total antioxidant activity of 41.4±0.45 µM Fe(II)/g. The EC50 values of ethanol extract for lipid peroxidation inhibitory activity and DPPH radical scavenging activity was found to be 0.1 and 0.5 mg/ml respectively. The anti-oxidant activities of other solvent extracts were poor when compared to the ethanol extract. These results suggest that, the active antioxidant compounds are better extracted in ethanol and there is a direct correlation between the total polyphenols extracted and its anti-oxidant activity. The invitro anti-oxidant activity of T. Catappa justifies the ethno medical use of this plant.