Roopa Karki

The objective of the present research was to develop and characterize an olive oil based oral microemulsion systems for famotidine, is a BCS class III drugs which are known to have high solubility but low permeability. An olive oil based microemulsion formulation with Tween-80 as surfactant, and PEG-400 as co-surfactant, was developed for oral delivery of famotidine. Pseudoternary phase diagram was constructed to determine the microemulsion existing zone. Optimized microemulsion was evaluated for its transparency, droplet size, polydispersity index, zeta potential, viscosity, conductivity, DSC studies, SANS studies. The results showed that maximum oil was incorporated in microemulsion system that was contained surfactant to co-surfactant ratio (Km) of 2:1. The optimized microemulsion formulation containing olive oil (7.14%), Tween-80 & PEG-400 [Smix=64.29% (2:1 ratio)], and distilled water (28.57%), had a droplet size (10 times diluted) and zeta potential (10 times diluted) of 170.1 nm and -6.58 mV respectively. Particle size characterization of the resulting microemulsion is essential in ensuring stability and efficient dosage. FTIR and DSC studies revealed the compatibility among the famotidine and microemulsion components. The experimental SANS data of optimized formulation fit well by spherical micelles interacting with hard sphere potential. These results demonstrate microemulsion formulation may be used as an effective and alternative drug delivery system for the antiulcer oral therapy with famotidine.

The main aim of research work was to design novel bilayer fast dissolving films as a drug delivery system for treatment of severe hypertension and acute cases like angina pectoris. In present work two incompatible drugs Amlodipine and Benazapril was combined in single dosage form using impermeable membrane. The thin films of both drugs were prepared by using different concentration of polymers, plasticizers and super disintegrants. The films were casted in to bilayer films using impermeable membrane. These prepared Bilayer films were characterized on basis of thickness, folding endurance, tensile strength and dissolution time. On basis of study it was found that the optimized film dissolves within 60 sec. and both drugs do not show interaction during preparation and stability period. The proposed novel films will deliver the two incompatible drugs and releases the drug quickly thus can be preferred in hypertension emergencies.