Rajesh Sharma

Hyperglycemia can be a serious problem if untreated in time. Chronic hyperglycemia that persists even in fasting states is most commonly caused by diabetes melitus, and in fact chronic hyperglycemia is the defining characteristic of the disease. Diabetes mellitus is the only non-infectious disease designated as an epidemic by the world health organization. This could have long lasting adverse effects on nation´s health and economic, especially for developing countries. the international diabetes federation(IDF) estimates the total number of people in India with diabetes to be around 50.8 million in 2010, rising to 87.0 million by 2030. The primary goal in the management of diabetes mellitus is the maintenance of blood glucose level.  Therefore, there is an urgent need to develop novel therapeutic agents without the development and progression of complications or compromising on safety. The present review provides an approach for the safe and effective treatment of diabetes melitus.

Pharmacoinformatics is new emerging information technologies like neuroinformatics, immunoinformatics, bioinformatics, Metabolomics, chemo-informatics, toxico-informatics, cancer informatics, genome informatics, proteome informatics, biomedical informatics are basic tools provided for the purpose of drug discovery. There is an increasing recognition that information technology can be effectively used for drug discovery. The work in pharmacoinformatics can be broadly divided into two categories - scientific aspects and service aspects. The scientific component deals with the drug discovery and development activities whereas the service oriented aspects are more patient centric. The compelling drivers for the pharmaceutical industry are minimizing the time between a drug’s discovery and its delivery to the marketplace and maintaining high productivity in the manufacturing processes. During a product’s lifecycle many complex decisions must be made to achieve these goals. To better support the development and manufacturing processes at each stage, we have proposed a new epitome to facilitate the management and transfer of data information and knowledge. In future these information technology efforts are expected to grow both in terms of their reliability and scope. Thus, this emerging technology (pharmacoinformatics) is becoming an essential component of pharmaceutical sciences.