Prashant S. Malpure

The goal of the current work is to use the wet granulation technology to make medication tablets using fenugreek extract. Additionally, research was done on the impact of sodium starch glycolate, a super disintegrant, on drug release and disintegration. Mucilage found in fenugreek extract slows down the disintegration of tablets, resulting in a slower release of the medication. Therefore, sodium starch glycolate was employed as a super disintegrant to enhance disintegration and, consequently, in vitro drug release. Wet granulation was used to make tablet formulations both with and without sodium starch glycolate. It was done to evaluate the granules' flow characteristics and characterize the physicochemical makeup of tablet formulations. The fundamental cause of fenugreek's antidiabetic effect is the alkaloid trigonelline, which is present in large amounts. For the treatment of diabetes, this study concludes that fenugreek seed extracts in tablet form with super disintegrants will be more desirable, useful, and therapeutically more effective than combining the plant components directly for a quicker commencement of action.

Parenteral delivery provides rapid onset even for the drug with narrow therapeutic window, but to maintain the systemic drug level repeated installation are required which cause the discomfort. Therefore, a delivery system that combines the simplicity and reliability of solid implant devices along with convenience and ease of administration on of micro-particles are desired. In situ gel forming system represents a desired alternate. The atrigel system is a proprietary delivery system that can be used for both parenteral and site specific drug delivery. it consist of biodegradable polymers dissolved in a biocompatible carriers when the liquid polymer system is placed in the body using standard needles and syringes, it solidifies upon contact with aqueous body fluids to form a solid implant. There are some advantages of these system are compatibility with a broad range of pharmaceutical compound, less invasive technique, direct delivery to a target area, protection of drug, sustained drug release, few type of atrigel are surgical implants, microspheres, liposomes and injectable gels.

Hydrogel product constitute a group of polymeric material, the hydrophilic structure of which render them capable of holding large amount of water in their three dimensional networks. Due to their high water content, porosity and soft consistency, they closely simulate natural living tissue, more so than any other class of synthetic biomaterials. Furthermore, hydrogels can be formulated in a variety of physical forms, including slabs, microparticles, nanoparticles, coatings, and films. As a result, hydrogels are commonly used in clinical practice and medicine for a wide range of applications, including Tissue engineering and Regenerative medicine, Diagnostics, Cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This biomaterial can hold large amount of biological fluids and swell. When swell, they are soft and rubbery and resemble the living tissue exhibiting excellent biocompatibility. The prime objective of this article is to concern the classification of hydrogel on different bases, properties of hydrogel and its method of preparation and physical and chemical characteristics of these products.