Pramila T.Gowda

Several pharmacological activities like anti-cancer, anti-microbial, antibacterial, antifungal, and anti-viral activity have been attributed to tetrahydrocarbazole. The above observations prompted us to synthesize some novel tetrahydrocarbazole derivatives as possible anticancer agents. A series of novel tetrahydrocarbazole derivatives have been synthesized by the reaction of tetrahydrocarbazole with substituted aromatic aldehydes. The starting material, tetrahydrocarbazole were prepared by Fischer indolisation reaction of cyclohexanone with phenylhydrazine in the presence of acetic acid. The cycloaddition of tetrahydrocarcazole and substituted aromatic aldehydes gives tetrahydrocarbazole derivatives (A1-A10). The structures of synthesized derivatives were confirmed by IR, 1HNMR and Mass spectrum. The synthesized compounds were screened for their in-vitro anticancer activity. The anticancer activity data of the synthesized derivatives were found to be potent activity. Key words: Phenyl hydrazine, Cyclohexanone, Tetrahydrocarbazole derivatives, In-vitro anticancer activity.

In the present scheme, we have an attempt to synthesize some novel benzimidazole derivatives by substituting triazole moiety at N-1 position of benzimidazole by fusion reaction of benzimidazole-1-acetic acid with thiocarbohydrazide. The substituted triazole was refluxed with different aromatic carboxylic acid in the presence of POCl3 yield different benzimidazole derivatives, respectively. The synthesized compounds were characterized by IR, 1H-NMR and Mass spectroscopy. The compounds were screened for antibacterial (gram +ve, gram –ve bacteria) activities. Key words: Benzimidazole, thiocarbohydrazide, substituted benzoic acid, benzimidazole- 1-acetic acid