Parwez Alam

The aim of present study was an effective novel strategy of combined plants extract for the treatment of Parkinson’s disease, using Amla Withania and Tulsi extract in different ratio. The extracts were prepared by using solvents like 60% ethanol for Amla fruit, 50% ethanol for Withania root and pure ethanol for Tulsi aerial part. Haloperidol was used to induce catalepsy and Akinesia. The ability of these combined extracts in inhibition of haloperidol-induced catalepsy and Akinesia in rodent models of Parkinsonian symptoms also Motor co-ordination test was conducted using a rota rod apparatus. It was found that treatment with the extract significantly reduced catalepsy according to dose.  In the second experiment haloperidol was used to suppress locomotor activity in test. Treatment with extract significantly increased locomotion reduced by haloperidol according to dose.

To investigate the phytoconstituents of ethanolic extract of Amorphophallus campanulatus decne tuber using GC-MS. GC-MS analysis of Amorphophallus campanulatus decne tuber was performed by using Agilent 6890 GC with 59739N MSD and GC -MS equipped with Elite–I fused with silica capillary column(Cpsil 8cb:30mm×25mm×0.25mm).The result of GC-MS analysis confirmed the presence of 10 compounds. The most prevailing compounds are heaxadecanoic acid, 9, 17-octadecadienal, Octadecanoic acid, heptacosane, 1-cholro, nosacosone, ergost-5-ene, stigmassterol, etc. the presence of phytoconstitutents reveals the presence of medicinal value.