Niraj Gupta

Phytoconstituents, in modern time phytosomes are being increase the level of natural remedies. It is recently introduced system to have used as a novel drug delivery. However nowadays it has been developed into the most well-turned and self assembled system to raise the oral bioavailability of phyto-drugs. That generally recognized as phytosomes. Phytoconstituents have a benignant moderation between hydrophilic and lipophilic in nature molecules which is helps in breakdown of gastro-intestinal sap to pass the lipid rich bio-membrane of cells. It can just be achieved as a result of phytosomes technique. But the delivery of herbal drugs is turn into the challenges owing to reduced aqueous dissolubility, poor permeations and foremost metabolite rate. Therefore, phytosome works as linkage for retain the efficiency toward develop the incorporation of numerous well-liked herbal drugs. E.g. - Ginkgo biloba, grape seeds, green tea etc. it can merely be evolved for a variety of remedial use.

There is a vast interest in the scientific community and drug industry to exploit various mucosal routes of delivering drugs, which are poorly absorbed after oral administration. Human rectum remains to be a relatively unexplored route of drug delivery despite its potential as a non- invasive route of drug administration. The presence of dense network of blood vessels has made the rectum an excellent route of drug delivery for both systemic and local effect. The present investigation was aimed to evaluating the possibility of using different surfactant i.e. Span 60 and 80, Tween 60 and 80 on the release rate of formulation for the development of rectal drug delivery system of paracetamol, an NSAIDs, to minimize the gastric irritation of the drug upon oral administration. Suppositories were formulated by fusion method & evaluated for their physicochemical characterization followed by in vitro evaluation through spectrophotometrically. Suppositories containing PEG 4000 with Tween 80 showed a better permeation of drug with faster dissolution rate in vitro than other formulations. The formulations were designed to overcome the risk of upper gastrointestinal complications such as stomach bleeding, and may cause kidney or liver damage. Suppositories are dosage forms for use in the unavoidable circumstances such as comatose, nauseous or vomiting.