N Pramod

The present study investigates the phytochemical composition of the ethanolic leaf extract of Allium fistulosum L. (Welsh onion) using Gas Chromatography–Mass Spectrometry (GC–MS). The analysis identified 38 bioactive compounds, including fatty acids, esters, sterols, alcohols, phenolics, and other secondary metabolites. Major constituents detected were n-hexadecanoic acid (27.81%), DL-Proline, 5-oxo-, ethyl ester (10.77%), γ-sitosterol (7.94%), 9, 12, 15-octadecatrienoic acid (4.60%), and phytol (4.22%). These compounds are reported to exhibit various pharmacological activity such as antimicrobial, antioxidant, anti-inflammatory, and potential anticancer activities. The phytoconstituents identified highlight the therapeutic relevance of A. fistulosum and provide scientific support for its traditional medicinal applications. The findings further suggest potential utility of this plant in pharmaceutical, nutraceutical, and cosmetic formulations.

Novel pyrano quinolone derivatives were synthesized by the treatment of p-methyl acetanilide upon treatment with DMF and POCL3 at 00 C it undergone cyclization reaction which gives 2-chloro-6-methyl quinolone-3-carbaldehyde and further treated the reaction with 4M HCL gives 2-hydroxy-6methyl quinolone-3-carbaldehyde is formed. The above reaction further treated with ethyl aceto acetate and piperidine by using grind stone technique with the elimination of ethanol and water gives 3-acetyl-7-methyl-2H- Pyrano[2,3-b] quinolone-2-one. The above reaction was further treated with 40% KOH and ethanol with different substituted aldehyde to give novel pyrano quinoline derivatives. Compounds which are synthesized are identified by MP and TLC as well as characterized by IR, 1HNMR and MASS spectroscopy. Docking studies were performed for anti-malarial activity using Plasmodium falciparum lactate dehydrogenase for a selected compounds shows good binding energy when compared to Chloroquine which is used as standard.