Manogna.K

In the present study, an attempt was made to develop pulsatile system of Nabumetone for effective management of colonic spasms. We tried to explore the feasibility of time dependent pulsatile drug delivery system of nabumentone to treat colon spasms. And also to prepare enteric coated tablets consisting of super disintegrates by direct compression method and to evaluate  for their quick release properties and disintegration.  Literature review has proved that Nabumetone , which undergoes  hepatic biotransformation, 6- methoxy -2-naptthylacetic acid a protein inhibitor  of prostaglandin synthesis through binding COX-1 and COX-2 receptors. Explosol used as super disintegrant and hydroxy propyl methyl cellulose (HPMC K100M), Eudragit as film former. Drug and excipients are studied for pulsatile release of precompressional tablets by using FT-IR spectrophotometry. Tablets were prepared by direct compression method. Evaluation of tablets by pre-compression parameters like angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio and post compressional parameters namely thickness, weight variation , Hardness, friability, dissolution studies, assement of kinetics of dissolution, zero order model, first order model, Higuci model, Korsmeyer-peppas model and stability studies were determined. All the obtained results from the tests were found to be within permissible limit. From the overall results, we can conclude that pulsatile tablets of nabumetone would deliver the drug according to the need of the patient for control of sever colon spasms.

  In present research work, a simultaneous estimation method of Vanillyl mandelic acid (VMA), 5 Hydroxy indole acetic acid (5-HIAA), Homovanillic acid (HVA), 6ß-Hydroxy cortisol using reverse phase HPLC method was developed and validated. Rat 24 hr urine samples were collected and injected directly without extraction, detection was carried out at 235 nm using UV detector. The developed method is précised, accurate and sensitive. Key words:  VMA, HVA, metabolic disorders, RP HPLC method.