Manjunath B Mendon

The main aim of research work was to design novel bilayer fast dissolving films as a drug delivery system for treatment of severe hypertension and acute cases like angina pectoris. In present work two incompatible drugs Amlodipine and Benazapril was combined in single dosage form using impermeable membrane. The thin films of both drugs were prepared by using different concentration of polymers, plasticizers and super disintegrants. The films were casted in to bilayer films using impermeable membrane. These prepared Bilayer films were characterized on basis of thickness, folding endurance, tensile strength and dissolution time. On basis of study it was found that the optimized film dissolves within 60 sec. and both drugs do not show interaction during preparation and stability period. The proposed novel films will deliver the two incompatible drugs and releases the drug quickly thus can be preferred in hypertension emergencies.