Manish Sinha

Mouth dissolving tablets (MDT) have received ever increasing demand during last decade and It is a rapidly a growing area in the pharmaceutical industry. After introduction into the mouth these tablets dissolve or disintegrate in the mouth and leaving an easy to swallow residue. Novel MDTs address the patient and pharmaceutical needs of convenient dosing particularly for busy or traveling patient, pediatric, geriatric and psychiatric patients who have difficulty in swallowing (dysphagia) conventional tablets and capsules. These tablets also have faster onset of action due to buccal absorption of the drug. The popularity and usefulness of the formulation resulted in development of several MDT Technologies. It is expected that this delivery system will get more importance in future as that of conventional delivery systems.

Solvents are widely used during the manufacturing, purification and processing of pharmaceutical substances. The residues of these solvents must be removed to the extent possible, as they do not have any therapeutic effect but can cause undesirable effects in the consumers. These solvent residues concentration should not exceed the limits prescribed in the ICH guidelines.  This present review work is emphasized on various techniques (Loss on drying, karl fischer titration, Thermogravimetric analysis, Near- IR spectroscopy, Thermal desorption GC-MS, Gas chromatography, Nuclear magnetic resonance spectroscopy) that are being used to remove the residual solvents with their merits and demerits.