M.R. Patel

The aim of present investigation was to develop press coated tablet for pulsatile drug delivery of lornoxicam using hydrophilic and hydrophobic polymers. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of rheumatoid arthritis. The press coated tablets containing lornoxicam in the inner core was formulated with an outer shell by different weight ratio of hydrophobic polymer (ethyl cellulose) and hydrophilic polymers (sodium alginate). The release profile of press coated tablet exhibited a lag time followed by burst release, in which outer shell ruptured into two halves. The effect of formulation composition on the barrier layer comprising both hydrophobic and hydrophilic excipients on the lag time of drug release was investigated. It was observed that lag time decreases with increasing concentration of sodium alginate. The optimized formulation (F5) comprised 10: 90%w/w concentration ratio of sodium alginate: Ethocel 10 cps with a 245 mg coating weight, and showed a desired lag time of 308 minutes, which mimics the fluctuating symptoms of rheumatoid arthritis, followed by rapid release of lornoxicam.

Nicotinic acid (NA) although known since decades, as an lipid lowering agent drug has not become a first-line treatment due to the strong side effect called flushing occurs when given in Immediate release (IR)dosage form. In the present research, an attempt has been made to formulate extended release matrix tablets of Nicotinic acid (NA). The tablets were prepared by wet granulation method and the prepared tablets of NA will remain intact up to 2 hrs even in pH 1.2 due to eudragit L 100-55 and its release is not only initiated but tact fully retarded up to 12 hrs and were found to be superior in physical properties, dissolution characteristics, and drug content uniformity. The in vitro NA release data justified the release mechanism to be Case-III and dissolution control release was found to be a mixed pattern of zero order and Korsmeyer-Peppas release models. Moreover, lactose shows moderately affected drug release due to channeling action and hence causing drug release at desired rate and amount.