Kishor Sahebrao Salunkhe

Oral administration of different dosage forms is the most common form of administration due to greater patient compliance. Time-dependent drug delivery systems have been widely used for colon-targeted delivery. This study, Eudragit RS 100 was used as a Time-dependent polymer. Single pH-dependent NPs (pH-NPs), single time-dependent NPs (Time_NPs), and dual pH/time-dependent NPs (pH-NPs) were prepared using the oil-in-water emulsion method. In present study colonic drug delivery is prepared in form of nanoparticles by using oil in water or Nano precipitation method. Nanoparticles having various advantages over tablets or capsules as short gastric residence time, improved bioavailability.

In pharmaceutical industry the major problem of dosage form development is low aqueous solubility. In present review the particle engineering concept and solubility, permeability approaches design and method used in improvement of particle size. The different methods are used in particle engineering like supercritical fluid technology, controlled precipitation, and mechanical technique, evaporation precipitation to aqueous solution, freezing technique, and sonication technology etc. discussed. The improvements of aqueous solubility need to be formulation development for dosage form very essential. The BCS class II drugs modified to soluble form for need of bioavailability of drugs. The solid dispersion method with a different carrier improves the solubility.

The purpose of writing this review article on gastro- retentive drug delivery systems (GRDDS) have been developed; the principle mechanism of floatation to achieve gastric retention. The recent developments of (FDSS) including the physiological and formulation variables affecting the gastric retention. Several techniques such as floating drug delivery system, low density systems, raft systems, mucoadhesive systems, high density systems, super- porous hydro- gels and magnetic systems, have been employed. Floating drug delivery systems have a bulk density less than gastric fluids and so, remain buoyant in the stomach for a prolonged period of time, releasing the drug slowly at the desired rate from the system. Dosage forms available as gastric floating systems include tablets, capsules, granules and microspheres.

Liposome proved themselves as a promising novel delivery vehicle of drugs to the skin, is a topic of considerable current interest. Liposomes are acceptable and superior carriers having ability to encapsulate both hydrophilic and lipophilic drugs and protect them from degradation. Liposomes are result of self-assembly of phospholipid in an aqueous media resulting in closed bilayer structures. Liposomes are one of unique drug delivery system which can be used in controlling and targeting drug delivery system. Liposomes are generally classified based upon structure, method of preparation, composition and application, conventional liposome, and specialty liposome. Different marketed formulations are available in market for liposomes. The liposomes have many applications which increase its importance over other formulations. The entrapped compound’s solubility and partitioning characteristics will determine its location in the liposomal bilayer .It also has affinity to keratin of horny layer of skin and can penetrate deeper into skin hence give better absorption. But they may also have the property into the skin, carrying actives to the target site, where these molecules will be released. Reformulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents. This review discusses the potential advantages in topical drug delivery, basic structure characteristics and mechanism of action of liposomes and evaluation parameter for liposome formulation.

Nanocochleates are unique novel drug delivery system in which, the desire drug molecule gets encapsulated into the multilayer of lipid crystal matrix. The nanocochleates structure provides protection to encochleated molecules from the degradation. It composed of negatively charged lipid generally phosphatidylserine and calcium. The nanocochleate structure has potential to carry the molecules which are hydrophobic, positively charged, negatively charged and that possess poor oral bioavailability. Nanocochleates is having more advantages than that of other dosage forms and system and hence it represents a new technology for oral and systemic delivery of drugs.