K.Rama Krishna
Author Profile
Department of Chemistry, GIS, GITAM University, Visakhapatnam – 530045, AP, INDIA
1
Publications
1
Years Active
3
Collaborators
52
Citations
Publications by K.Rama Krishna
1 publication found • Active 2015-2015
2015
1 publicationRP-HPLC Method development and validation for the Estimation of Etoposide in Bulk Drug and its Pharmaceutical Dosage Form.
with B.Lakshmi, K.N.Jayaveera, G.V.Padmakar rao
4/1/2015
A specific and accurate HPLC method is developed for the determination of etoposidein bulk drugs and in solid capsule dosage form. Best symmetric peak shape obtained with Inertsil ODS C-18 column (250 X 4.6 mm, 5μ) column in an isocratic mode, with retention time 5 min.The mobile phase used was Water : Acetonitrile 60:40(v/v)with flow rate 1.0 ml/min and effluent was monitored at 263 nm. As per ICH guidelines method has validated. Method has found linear in the range of 5-45 µg/ml. The LOD and LOQ were found to be 0.02 and 0.06 µg/ml respectively. Method was found specific with respective of diluents, excipients and degradants.
Author Statistics
Total Publications:1
Years Active:1
First Publication:2015
Latest Publication:2015
Collaborators:3
Citations:52
Research Topics
Collaborators