K. R. Khandelwal

The simple, accurate, precise, sensitive, specific and cost- effective UV-VIS Spectrophotometric method was developed for the estimation of acyclovir in bulk and pharmaceutical dosage form, used as an antiviral drug. The absorption maxima of the drug were found to be 252.6nm. in 0.1N H2SO4solvent. The method was validated as per the ICH Guidelines. A linear response was observed in the range of 2-10µg/ml with a regression coefficient of 0.999. The developed method was precise; the % RSD was found to be less than 2%. The LOD & LOQ were found to be 2.3 and 7.0µg/ml respectively. The standard drug was subjected to acidic, alkaline, oxidative, thermal & photolytic stress degradation conditions. The samples so generated were used for degradation studies using the stability indicating UV-Visible Spectrophotometric method. This method was used for the determination of Acyclovir in tablet and cream formulation without interferences of the excipients, this indicated specificity of method.

The present research work was to design and develop an optimized oro-dispersible tablet dosage form of an anti-psychotic drug, Olanzapine by using direct compression technology.  Total number of nine formulations were prepared as per the standard experimental design protocol using Design Expert Software (Version 8.0.5, Stat-Ease, Inc.). Independent variables such as the amount of the amount of Crospovidone XL 10 (A) and the amount of Avicel PH 102 (B) were optimized by application of Response surface methodology using Central Composite Design. The dependent variables selected were in-vitro dispersion time and wetting time of the tablets. All the evaluated physical parameters of the oro-dispersible tablets were practically within control. The direct compression method used to prepare the oro-dispersible tablets in this study is relatively simple, safe and economic. A stable, effective and pleasant tasting mouth dissolving tablet, which has a good balance over all the physical parameters was formulated.