K. R. Biyani

Pioglitazone HCl is an antidiabetic drug in thiazolidinediones group and it improves insulin sensitivity in insulin resistant patients. The drug has low solubility in biological fluid, lead to the poor bioavailability after oral administration. The present study aims at enhancement of dissolution profile of Pioglitazone HCl using Hupu gum (HG) and modified Hupu gum (MHG) as carriers by solid dispersion technique. MHG was prepared by heating at different temperature. The HG and MHG were characterized for viscosity, swelling index and water retention capacity.  Solid dispersion was prepared by cogrinding method using HG and MHG in the ratio 1:1 and 1:2 respectively. The solubility data shows that solubility of Pioglitazone HCl is increases with HG and found high in MHG. The FTIR and XRD study was carried out. The X-Ray diffraction study shown crystalline nature of pure drug, which was converted into amorphous form in solid dispersion. The optimized formulation shows the higher in vitro drug release (93.49 %) within 120 min and also it shows higher absorption against pure Pioglitazone HCl. From this study it concludes that MHG could be novel approach useful as a carrier with in enhancing solubility in solid dispersion.