K Krishnakumar

Diabetes mellitus is a disease that affects the way the body produces and uses insulin to control blood sugar. Basal bolus insulin therapy is a combination of short and long acting insulin. But, now a days there is a deadline in this therapy due to the use of automatic insulin pump and continuous glucose monitoring. It reduces A1C without any risk of hypoglycemia. This article review regarding role of basal bolus therapy in diabetes and in depth understanding of DDT including its dose calculation

Corticosteroids are the drugs used for multifarious diseases because of their widespread action. It is suggested that these drug use should not be ceased rapidly, rather than it should be finished gently. Due to their diversity of actions and uses, more no of interactions with the drugs and diseases were recorded. It is well known that there is a strong relationship between corticosteroid use and psychiatric effects. Both the steroid induced psychiatric symptoms and diagnosis are uncertain. Hence Pharmacists are the best person to mould a suitable drug therapy and a management regimen for corticosteroids induced adverse events in patients. They can also play an important role in educating the patients about corticosteroids and their psychic disturbances. Since physicians do not take any interest in to alert the patients about the usage, interactions and highly severe psychiatric problems of steroids, the need of pharmacists becomes very important.

Nanoemulsions appeared as a novel drug delivery system which allows controlled or sustained release of drug and biological active ingredients. Nanoemulsion is a dispersion consisting of oil, surfactant and an aqueous phase, which is an isotropically clear and thermo-dynamically or kinetically stable liquid solution, usually with droplet diameter within the range of 1-100 nm. This review gives the idea about the nanoemulsions system and provides brief information about the method of preparation and evaluation of nanoemulsion as well as various pharmaceutical applications of nanoemulsions in drug delivery including parenteral and pulmonary drug delivery, cosmetics, cancer therapy, vaccine delivery, formulations for improved oral delivery of poorly soluble drug and in cell culture technology.

Diabetes Mellitus is a metabolic disorder characterized by high blood glucose level caused by deficiency of insulin secretion or insulin action. Postprandial blood glucose level in patients with type II diabetes may be controlled by inhibition of alpha amylase, which is one of the carbohydrate hydrolysing enzymes. Alpha amylase is an enzyme which breaks down starch to maltose by hydrolysing alpha bonds of large, alpha-linked polysaccharides, such as starch and glycogen. Alpha amylase inhibitors may be useful as adjuvant drugs in type II diabetes. The objective of this review is to gather information regarding the identification and evaluation of alpha amylase inhibitors from natural and synthetic sources.