John Wesly I

Over the past years it has been recognized that women are more susceptible to coronary heart disease than men and it should be acknowledged in the management and assessment of coronary heart disease. Then there is a remarkable progress in the knowledge of cardiovascular risk factors related to gender. Triglycerides, high density lipoproteins levels, diabetes have been found to have greater Influence on coronary heart disease in women than men. But certain evidence showing that lipoprotein is a stronger cardiovascular risk factor in men compared to women. Risk factor control in patient with CHD remains poor, especially for obesity, smoking, and blood pressure in spite of guidelines. Patient should initiate or maintain lifestyle modification- weight control, increased physical activity, moderation of alcohol intake, limited sodium consumption, maintenance of a diet high in fresh fruits, low fat dairy products etc. Long acting drugs also minimize blood pressure variability and this may offer protection against progression of target organ damage and cardiovascular events. This review article addresses the impact of cardiovascular risk factors on both men and women and management of coronary heart disease.

Coronary artery disease is a condition in which there is an inadequate supply of blood and oxygen to a portion of the myocardium. It is the major cause responsible for mortality more in younger age group than in elderly. Since it is an emergency condition where usage of many drugs during its management is common. The study of drug utilization is a component of a medical audit and periodic evaluation should be done to enable suitable modifications in the prescription of drugs and maximize the therapeutic benefit and minimize the adverse effects. When new drugs are used additional information on safety and efficacy may be generated. In this review most of the prescription contain anti-platelet drugs, ACE inhibitors/ ARBs, Statins, Beta-blockers, Nitrates, Calcium channel blockers and Diuretics. Keywords: Drug Utilization, Coronary Artery Diseases, Anti- Platelet Drugs